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Related Experiment Videos

T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines.

W W Agace1, J M Higgins, B Sadasivan

  • 1Immunology Section, Department of Cell and Molecular Biology, Lund University, Sweden.

Current Opinion in Cell Biology
|September 9, 2000
PubMed
Summary

T cells use specific adhesion molecules and chemokine receptors to reach epithelial tissues. Recent research clarifies interactions with E-cadherin and identifies a new molecule, LEEP-CAM, aiding T cell homing to skin and gut epithelia.

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Area of Science:

  • Immunology
  • Cell Biology
  • Epithelial Biology

Background:

  • Epithelia form protective avascular cell layers on body surfaces.
  • T cells migrate to epithelial sites through specific molecular interactions.
  • Understanding these interactions is crucial for immune surveillance and response.

Purpose of the Study:

  • To elucidate the mechanisms of T cell localization to epithelial tissues.
  • To detail the roles of adhesion molecules and chemokines in T cell homing.
  • To highlight recent advancements in understanding these cellular interactions.

Main Methods:

  • Investigated the alpha(Ebeta7) integrin and its interaction with E-cadherin.
  • Identified and characterized a novel adhesion molecule, LEEP-CAM, on non-intestinal epithelial cells.

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  • Analyzed the function of epithelial-derived chemokines in regulating T cell migration.

    • Main Results:

    • Advanced understanding of the alpha(Ebeta7) integrin-E-cadherin binding.
    • Discovered LEEP-CAM (lymphocyte-endothelial-epithelial-cell adhesion molecule) on non-intestinal epithelial cells.
    • Demonstrated the role of skin- and gut-epithelia-derived chemokines in directing activated T cell homing.

    Conclusions:

    • T cell homing to epithelia is regulated by specific adhesion molecules and chemokines.
    • New insights into alpha(Ebeta7) integrin, E-cadherin, and LEEP-CAM interactions are key.
    • Epithelial-derived chemokines play a significant role in guiding T cell populations to specific sites.