Related Experiment Videos
Mechanism of homophilic cadherin adhesion
1Department of Chemical Engineering, University of Illinois, Urbana, Illinois 61801, USA. leckband@uiuc.edu
Current Opinion in Cell Biology
|September 9, 2000
Abstract:
Direct measurements of the distance-dependent forces between membrane-bound cadherins were used to test current models of homophilic cadherin interactions. The results reveal a complex binding mechanism in which the proteins adhere in multiple alignments that involve more than the amino-terminal domains.