Related Experiment Video
Updated: Jul 29, 2026
07:48
Working with Human Tissues for Translational Cancer Research
Published on: November 26, 2015
The future of clinical research
1Department of Medicine, Vanderbilt University, Nashville, Tenn., USA. david.robertson@mcmail.vanderbilt.edu
Summary
The commentary addresses the crisis in clinical investigation and the challenges faced by physician-scientists. It highlights the need for advocacy and support for human experimentation careers.
Area of Science:
- Medical Research
- Clinical Investigation
- Physician-Scientist Careers
Background:
- The commentary discusses the crisis in clinical investigation, impacting careers focused on human experimentation.
- It references the inaugural meeting of the Association for Patient-Oriented Research (APOR) in 1999.
Discussion:
- The American Federation for Medical Research (AFMR) advocates for physician-scientists and their research.
- AFMR's efforts influenced the Clinical Research Enhancement Act, leading to NIH awards (K30, K23, K24).
Key Insights:
- The formation of APOR signifies the critical need for patient-oriented research.
- Collaboration through initiatives like Clinical Research 2001 aims to address challenges in clinical research.
Outlook:
- AFMR is committed to supporting clinical investigators as a vital part of future medical research.
- Continued advocacy and collaborative efforts are essential for the advancement of clinical research.
Related Concept Videos
01:29Issues And Trends In Healthcare Delivery System
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
01:16Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
01:11Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
01:28Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...