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[Misoprostol-induced pneumonitis].

T Matsumoto1, K Nakamura, K Sugisaki

  • 1Third Department of Internal Medicine, Oita Medical University, Japan.

Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society
|September 9, 2000
PubMed
Summary

This case report details a rare instance of drug-induced interstitial pneumonia. Misoprostol was identified as the likely cause in a patient experiencing respiratory distress.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Pathology

Background:

  • Rheumatoid arthritis management often involves multiple medications.
  • Interstitial pneumonia is a serious potential adverse effect of certain drugs.

Observation:

  • A 76-year-old woman presented with severe hypoxemia, dyspnea, and non-productive cough.
  • Imaging revealed diffuse interstitial infiltrates, and biopsy showed characteristic inflammatory changes.
  • The patient had been treated with misoprostol, sodium aurothiomalate, prednisolone, and loxoprofen sodium.

Findings:

  • Drug-induced interstitial pneumonia was suspected and confirmed through diagnostic testing.
  • Misoprostol was implicated as the causative agent via lymphocyte stimulation and dermal patch tests.
  • Treatment with medication withdrawal and corticosteroids led to significant clinical and radiological improvement.

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Implications:

  • This case highlights misoprostol as a potential cause of interstitial pneumonia.
  • Early identification and cessation of the offending drug are crucial for patient recovery.
  • Awareness of this adverse effect is important for clinicians managing patients on misoprostol.