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[Proteinase-proteinase inhibitor complex in rats under oxidative stress caused by administration of cobalt chloride]
P A Kaliman1, A A Samokhin, L M Samokhina
1Kharkov State University.
Ukrains'Kyi Biokhimichnyi Zhurnal (1999 )
|September 9, 2000
Abstract:
Mechanisms of proteinase-inhibitor proteinase system response was estimated following of cobalt chloride injection. The increase proteinase activity, which led to significant decrease of alpha-2-macroglobulin (alpha-2-MG) level was established that indicated to the removal of the proteinase in complex with alpha-2-MG from the organism. Increase of alpha-1-proteinase inhibitor (alpha-1-PI) trypsin-inhibitory activity in the kidneys testify about removal of oxidative alpha-1-PI.