[Urapidil effects on oxidative stress in hypertensive crises]

Area of Science:

• Cardiology
• Biochemistry

Background:

• Hypertensive crises are associated with significant oxidant stress.
• Oxidant stress markers, including lipid peroxidation (LPO) and antioxidant system (AOS) status, are elevated during hypertensive crises.

Purpose of the Study:

• To investigate the effects of urapidil on oxidant stress in patients experiencing hypertensive crises.
• To evaluate the impact of urapidil and subsequent combination therapies on oxidant stress markers and hormonal balance.

Main Methods:

• 36 patients with stage I-III hypertension and crisis were treated with intravenous urapidil, followed by monotherapy and combination therapy.
• Lipid peroxidation (LPO), antioxidant system (AOS) status, hydrocortisone, and insulin levels were measured at multiple time points before and after treatment.

Main Results:

• Urapidil administration significantly reduced hydrocortisone, dienic conjugates, lipid peroxidation, and oxidant stress rate (OSR).
• While LPO and OSR initially decreased, they showed a slow increase in the later stages of the study.
• Hormonal levels related to catabolism and anabolism were also monitored throughout the treatment period.

Conclusions:

• Urapidil demonstrates efficacy in mitigating oxidant stress during hypertensive crises.
• The findings support the use of antioxidants in the management of hypertensive patients experiencing crises.