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Deletions at 11q23 in different lymphoma subtypes
1Department of Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Haematologica
|September 12, 2000
Summary
The 11q23 deletion is common in mantle cell lymphoma (MCL), B-cell chronic lymphocytic leukemia (CLL), and diffuse large cell lymphoma (DLCL). This deletion may correlate with lymphoma transformation and Richter's syndrome development.
Area of Science:
- Oncology
- Genetics
- Hematology
Background:
- Chromosome band 11q23 deletions are frequent in neoplasms.
- Yeast artificial chromosome (YAC) clone 755b11 at 11q23 represents a minimal common deletion region in mantle cell lymphoma (MCL) and B-cell chronic lymphocytic leukemia (B-CLL).
Purpose of the Study:
- To determine the frequencies of 11q23 deletion across various lymphoma subtypes.
- To investigate the association of 11q23 deletion with specific lymphoma types and clinical outcomes.
Main Methods:
- Fluorescence in situ hybridization (FISH) analysis using YAC755b11.
- Analysis of peripheral blood or lymph node biopsy specimens from patients with MCL, CLL/SLL, DLCL, follicular lymphoma (FL), and Hodgkin's disease (HD).
- Inclusion of reactive/normal lymph node biopsies as controls.
Main Results:
- Twenty-five percent (40/161) of samples exhibited 11q23 deletion.
- Deletions were observed in MCL (49%), CLL/SLL (21%), and DLCL (24%).
- All three Richter's syndrome cases showed 11q23 deletion; significant differences in deletion frequencies were noted between blood and lymph node specimens in CLL/SLL.
Conclusions:
- 11q23 deletion is not common in lymphomas outside of MCL, CLL, and DLCL.
- The 11q23 deletion may correlate with lymphoma transformation to CLL and the development of Richter's syndrome.