Jove
Visualize
Contact Us

Related Experiment Videos

Triglycerides and coronary risk.

J M Gaziano1

  • 1VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA 02132, USA.

Current Cardiology Reports
|September 12, 2000
PubMed
Summary

Elevated triglycerides are a useful marker for coronary heart disease (CHD) risk, despite measurement challenges. Further research is needed to clarify their independent role in CHD prevention and guide treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.

Nature genetics·2025
Same author

Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2024
Same author

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.

medRxiv : the preprint server for health sciences·2024
Same author

Long-Term Aspirin Use and Self-Reported Walking Speed in Older Men: The Physicians' Health Study.

The Journal of frailty & aging·2022
Same author

Aspirin has potential benefits for primary prevention of cardiovascular outcomes in diabetes: updated literature-based and individual participant data meta-analyses of randomized controlled trials.

Cardiovascular diabetology·2019
Same author

Vitamin B6 catabolism and lung cancer risk: results from the Lung Cancer Cohort Consortium (LC3).

Annals of oncology : official journal of the European Society for Medical Oncology·2019
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Epidemiology

Background:

  • The independent role of triglycerides as a risk factor for coronary heart disease (CHD) remains debated.
  • Triglyceride measurement variability and interactions with other factors complicate risk assessment.
  • Recent large-scale data suggest elevated fasting triglycerides are a significant CHD risk marker.

Purpose of the Study:

  • To evaluate the association between triglyceride levels and coronary heart disease (CHD) risk.
  • To explore the interplay between triglycerides, HDL, and LDL particle size in myocardial infarction.
  • To assess the impact of triglyceride-lowering interventions on CHD event rates.

Main Methods:

  • Analysis of large-scale epidemiologic data.
  • Review of clinical trial data on lipid-modifying therapies.
  • Examination of interrelationships between lipid parameters and CHD risk.

Main Results:

  • Elevated fasting triglycerides are a useful marker for CHD risk.
  • Triglyceride levels, HDL levels, and LDL particle size interact to increase myocardial infarction risk.
  • Interventions lowering triglycerides and raising HDL may reduce CHD events.

Conclusions:

  • Further research is warranted to define the role of triglycerides in CHD prevention across diverse subgroups.
  • The prognostic significance of fasting versus postprandial triglyceride levels requires clarification.
  • Screening and treatment guidelines may need revision to emphasize fasting triglyceride levels for CHD risk assessment and management.

Related Experiment Videos