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Insights into pathogenesis and treatment of cytokines in cardiomyopathy

L Vadlamani1, W T Abraham

  • 1Section of Heart Failure and Cardiac Transplantation, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0542, USA.

Current Cardiology Reports
|September 12, 2000
PubMed

Insights

Chronic heart failure involves proinflammatory cytokines like tumor necrosis factor-alpha and interlukin-6. Targeting these molecules shows promise for future heart failure treatments.

Area of Science:

  • Cardiology
  • Immunology
  • Pathophysiology

Background:

  • Chronic heart failure (CHF) pathophysiology is increasingly understood.
  • Proinflammatory and vasoconstrictive cytokines are implicated in CHF development and progression.

Purpose of the Study:

  • To review the role of specific cytokines in CHF.
  • To discuss the potential of cytokine-targeted therapies for CHF.

Main Methods:

  • Literature review of recent investigations.
  • Analysis of cytokine involvement in cardiac remodeling and dysfunction.

Main Results:

  • Tumor necrosis factor-alpha, interlukin-6, and endothelin are key implicated cytokines.
  • These cytokines contribute to ventricular dysfunction through various mechanisms.

Conclusions:

  • Cytokines play a significant role in chronic heart failure progression.
  • Investigational cytokine inhibitors offer potential therapeutic strategies for CHF.

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