Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonalcoholic fatty liver disease.

Z M Younossi1

  • 1The Cleveland Clinic Foundation, Department of Gastroenterology, Desk S-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Current Gastroenterology Reports
|September 12, 2000
PubMed
Summary

Nonalcoholic fatty liver disease (NAFLD) definitions vary, impacting study outcomes. Histologic features like ballooning indicate aggressive disease, while steatosis alone appears benign, highlighting the need for clear diagnostic criteria.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of hepatitis C virus leads to economic gains related to reduction in cases of hepatocellular carcinoma and decompensated cirrhosis in Japan.

Journal of viral hepatitis·2018
Same author

Editorial: direct-acting antivirals significantly improve quality of life in patients with hepatitis C virus infection-Author's reply.

Alimentary pharmacology & therapeutics·2018
Same author

Hospice care in Medicare patients with primary liver cancer: the impact on resource utilisation and mortality.

Alimentary pharmacology & therapeutics·2018
Same author

Quality of life in adolescents with hepatitis C treated with sofosbuvir and ribavirin.

Journal of viral hepatitis·2017
Same author

Sofosbuvir and velpatasvir with or without voxilaprevir in direct-acting antiviral-naïve chronic hepatitis C: patient-reported outcomes from POLARIS 2 and 3.

Alimentary pharmacology & therapeutics·2017
Same author

Impact of ledipasvir/sofosbuvir on the work productivity of genotype 1 chronic hepatitis C patients in Asia.

Journal of viral hepatitis·2017

Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions.
  • Its definition has evolved, encompassing entities similar to alcoholic liver disease.
  • Conflicting study conclusions may stem from nonuniform NAFLD definitions.

Purpose of the Study:

  • To review the current understanding of nonalcoholic fatty liver disease.
  • To discuss the limited available treatments for NAFLD.
  • To explore theories on the pathogenesis of NAFLD.

Main Methods:

  • Review of existing literature on nonalcoholic fatty liver disease.
  • Analysis of clinicopathologic entities within the NAFLD spectrum.
  • Correlation of histologic features with disease outcomes.

Main Results:

  • NAFLD is a nonspecific term including steatosis, steatonecrosis, and steatohepatitis.
  • Histologic features such as hepatocyte ballooning, necrosis, and Mallory hyaline are associated with aggressive NAFLD.
  • Isolated steatosis appears to have a benign clinical course.

Conclusions:

  • Clearer definitions are crucial for consistent NAFLD research.
  • Histologic findings are key to predicting NAFLD prognosis.
  • Understanding NAFLD pathogenesis is essential for developing effective treatments.

Related Experiment Videos