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Intestinal transplantation in children

L Sigurdsson1, J Reyes, S A Kocoshis

  • 1Department of Pediatric Gastroenterology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213-2583, USA.

Current Gastroenterology Reports
|September 12, 2000
PubMed

Insights

Intestinal transplantation offers a lifesaving option for children with intestinal failure and complications from total parenteral nutrition. This procedure addresses irreversible liver injury and loss of vascular access, benefiting many annually.

Area of Science:

  • Gastroenterology and Hepatology
  • Pediatric Surgery
  • Transplantation Medicine

Background:

  • Intestinal failure is a severe condition often requiring total parenteral nutrition (TPN).
  • TPN can lead to life-threatening complications, including irreversible liver injury and loss of vascular access.
  • Intestinal transplantation has become a viable therapeutic option for select pediatric patients.

Purpose of the Study:

  • To discuss the indications for intestinal transplantation in children.
  • To outline the pre- and postoperative management strategies for pediatric intestinal transplant recipients.
  • To review the outcomes associated with intestinal transplantation in the pediatric population.

Main Methods:

  • This article provides a comprehensive review of current practices and outcomes.
  • Information is synthesized from existing literature and clinical experience.
  • Focus is on pediatric cases requiring intestinal transplantation due to intestinal failure.

Main Results:

  • Intestinal transplantation is indicated for children with irreversible liver injury or loss of vascular access due to TPN complications.
  • Careful pre- and postoperative management is crucial for successful outcomes.
  • The procedure offers a lifesaving alternative for eligible pediatric patients.

Conclusions:

  • Intestinal transplantation is a critical intervention for pediatric intestinal failure.
  • Successful outcomes depend on meticulous management protocols.
  • Further research and advancements continue to improve the efficacy of this procedure.

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