Nitric oxide and the gut
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Updated: Oct 13, 2026

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements
Published on: July 29, 2021
D Jourd'heuil1, M B Grisham, D N Granger
1Vascular Biology Research Group, MS 113, Department of Physiology and Cell Biology, Albany Medical College, 47 New Scotland Avenue (MC 8), Albany, NY 12208, USA.
Abstract:
Nitric oxide (NO) has been implicated as a modulator of blood flow, motility, electrolyte and water transport, and the function of endothelial cells, platelets, mast cells, and macrophages within the digestive system. In addition, a number of reports have demonstrated that NO possesses potent anti-inflammatory properties, whereas results from an equally impressive number of studies suggest that NO may promote inflammation-induced cell and tissue dysfunction. Consideration of the physiologic chemistry of NO and its interaction with molecular oxygen and/or superoxide may allow us to identify which of the NO-dependent reactions are important in modulating physiologic and pathophysiologic responses in the gut.
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