Advances in zinc finger engineering

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Updated: Oct 13, 2026

Genome Editing with CompoZr Custom Zinc Finger Nucleases (ZFNs)
09:11

Genome Editing with CompoZr Custom Zinc Finger Nucleases (ZFNs)

Published on: June 14, 2012

Y Choo1, M Isalan

  • 1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. choo@mrc-lmb.cam.ac.uk

Current Opinion in Structural Biology
|September 12, 2000
PubMed

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...