Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Complement component 9 deficiency is not a susceptibility factor for SLE.

S Kanemitsu¹, K Ihara, R Kira

¹Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. satomi@mailserver.med.kyushu-u.ac.jp

|September 12, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Breath-hold diffusion-weighted MR imaging (DWI) using deep learning reconstruction: Comparison with navigator triggered DWI in patients with malignant liver tumors.

Radiography (London, England : 1995)·2024

Same author

Factors related to dissociation between objective and subjective masticatory function in Japanese community-dwelling elderly adults.

Journal of oral rehabilitation·2018

Same author

Frailty Severity and Dietary Variety in Japanese Older Persons: A Cross-Sectional Study.

The journal of nutrition, health & aging·2018

Same author

Relationship between Sensory Perception and Frailty in a Community-Dwelling Elderly Population.

The journal of nutrition, health & aging·2017

Same author

FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children.

Diabetic medicine : a journal of the British Diabetic Association·2016

Same author

Variants associated with autoimmune Type 1 diabetes in Japanese children: implications for age-specific effects of cis-regulatory haplotypes at 17q12-q21.

Diabetic medicine : a journal of the British Diabetic Association·2016

Complement component 9 (C9) deficiency, common in Japan due to the Arg95Stop mutation, was investigated for its link to systemic lupus erythematosus (SLE). The study found no significant difference in C9 deficiency prevalence between SLE patients and controls, suggesting it does not increase SLE risk.

Area of Science:

Immunology
Genetics
Rheumatology

Background:

Complement component 9 (C9) deficiency is primarily linked to the Arg95Stop mutation in the Japanese population.
Systemic lupus erythematosus (SLE) is an autoimmune disease with complex genetic and environmental factors.

Purpose of the Study:

To investigate the association between C9 deficiency, specifically the Arg95Stop mutation, and susceptibility to SLE.
To determine the carrier frequency of the Arg95Stop mutation in SLE patients and healthy controls.

Main Methods:

Genotyping for the Arg95Stop mutation in the C9 gene.
Comparison of carrier frequencies between 78 SLE patients and a control group.

Main Results:

The carrier frequency of the Arg95Stop mutation did not significantly differ between SLE patients and controls.

Related Experiment Videos

No statistically significant association was found between C9 deficiency and SLE susceptibility.

Conclusions:

C9 deficiency, despite its prevalence in Japan due to the Arg95Stop mutation, does not appear to be a significant risk factor for developing SLE.
Further research may explore other complement system components or genetic factors in SLE pathogenesis.