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A preliminary report on cephradine.

W P Leary, A C Asmal, C J Lockett

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 2, 1975
    PubMed
    Summary
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    Cephradine plasma levels were assessed following oral and parenteral routes in healthy adults. Parenteral administration yielded higher cephradine concentrations than oral, with satisfactory outcomes in urinary tract infection patients.

    Area of Science:

    • Pharmacokinetics
    • Clinical Pharmacology

    Background:

    • Cephradine is a first-generation cephalosporin antibiotic.
    • Understanding cephradine pharmacokinetics is crucial for effective treatment regimens.

    Purpose of the Study:

    • To determine plasma cephradine levels after oral and parenteral administration.
    • To evaluate the clinical efficacy of cephradine in treating urinary tract infections.

    Main Methods:

    • Healthy adults received oral or parenteral cephradine (0.5 g).
    • Plasma cephradine concentrations were measured over time.
    • An open clinical trial was conducted on 10 patients with urinary tract infections.

    Main Results:

    • Oral administration resulted in plasma concentrations of 7-15 mug/ml.

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  • Parenteral administration achieved higher concentrations of 12-57 mug/ml.
  • Concentrations decreased to 3 mug/ml within 240 minutes, except after intramuscular administration.

    • Conclusions:

    • Parenteral administration of cephradine leads to higher plasma concentrations compared to oral administration.
    • Cephradine demonstrated satisfactory results in treating urinary tract infections.