Relation between choice of partner and high frequency of connexin-26 deafness
1Department of Human Genetics, Virginia Commonwealth University, Richmond 23298-0033, USA. nance@hsc.vcu.edu
Abstract:
Recessive mutations at the connexin-26 gene locus are now recognised as the cause of nearly half of all cases of genetic deafness in many populations. We suggest that this high frequency is only seen in populations with a long tradition of intermarriage among deaf people. Available data are consistent with the hypothesis that such marriages might well have contributed to the high frequency of connexin-26 deafness in the USA, and could represent a novel mechanism for maintaining specific genotypes at unexpectedly high frequencies.
More Related Videos
Related Concept Videos
The Cochlea
Gap Junctions
¹H NMR Signal Multiplicity: Splitting Patterns
Spin–Spin Coupling Constant: Overview
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must have a...
Gap Junctions
Auditory Pathway
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...


