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Published on: May 30, 2011
Measurement of hepatic perfusion with dynamic computed tomography: assessment of normal values and comparison of two
T R Bader1, F Grabenwöger, R W Prokesch
1Department of Radiology, University of Vienna, Austria. till.bader@univie.ac.at
Rationale And Objectives:
To assess normal values of hepatic perfusion by dynamic, single-section computed tomography, to compare two methods of data processing (a smoothing with a fitting procedure), and to evaluate the influence of motion artifacts.
Methods:
Twenty-five volunteers with no history or suspicion of liver disease were examined (age range, 32.8-81.1 years). All examinations were subjectively ranked into groups 1 through 3 according to the degree of motion artifacts (negligible, moderate, severe). All data were processed with a smoothing procedure and a pharmacokinetic fitting procedure (TopFit). The arterial, portal venous, and total hepatic perfusion; the hepatic perfusion index (HPI); and the arterial/portal venous ratio (A/P ratio) were calculated with both procedures.
Results:
Mean hepatic perfusion, as assessed with the fitting procedure and the smoothing procedure, respectively, was as follows: arterial, 0.20 and 0.22 mL x min(-1) x mL(-1); portal venous, 1.02 and 1.24 mL x min(-1) x mL(-1); total perfusion, 1.22 and 1.47 mL x min(-1) x mL(-1); HPI, 16.4% and 15.4%; and A/P ratio, 0.20 and 0.19. The differences were significant for the portal venous and total hepatic perfusion. The portal venous and total hepatic perfusion values showed significant differences between group 1 and groups 2 and 3 for both procedures. HPI and the A/P ratio showed no significant differences at all.
Conclusions:
Motion artifacts and the type of data processing influence the assessment of the arterial, portal venous, and total hepatic perfusion but do not influence measurement of the HPI and the A/P ratio.
