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Ovarian ependymoma. A case report.

V Garcia-Barriola1, M N De Gómez, J A Suárez

  • 1Instituto Anatomopatológico Dr. Jose A. O'Daly, Universidad Central de Venezuela, Sabana Grande, Caracas.

Pathology, Research and Practice
|September 12, 2000
PubMed
Summary

This case report details a rare bilateral ovarian ependymoma, initially misdiagnosed as ovarian cancer. Diagnosis was confirmed via histology, showing ependymal rosettes and GFAP positivity.

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Area of Science:

  • Gynecologic Oncology
  • Neuropathology
  • Rare Tumors

Background:

  • Ovarian tumors can present diagnostic challenges, mimicking common malignancies.
  • Accurate diagnosis is crucial for appropriate patient management and prognosis.

Observation:

  • A 30-year-old woman presented with pelvic pain and was initially misdiagnosed with ovarian carcinoma.
  • Surgical exploration revealed bilateral ovarian ependymoma with uterine infiltration and omental implants.
  • Histopathological examination confirmed ependymoma with characteristic rosettes and glial fibrillary acidic protein (GFAP) positivity.

Findings:

  • The ovarian tumor was identified as a pure ependymoma, distinct from common ovarian cancers like endometrioid or small cell carcinoma.
  • This represents one of the few reported cases of ovarian ependymoma in the literature.

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  • No teratomatous elements were found, indicating a pure ependymal origin.

    • Implications:

    • Ovarian ependymomas, though rare, appear to have a favorable prognosis.
    • Early and accurate diagnosis, supported by immunohistochemistry (GFAP), is vital.
    • Successful treatment involves surgery and chemotherapy, even in advanced stages.