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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Fever of unknown origin in a 10-year-old boy with allergic rhinitis and asthma

A Z Caliskaner1, M Karaayvaz, N Ozanguc

  • 1Department of Allergy, GATA Gulhane Military Medical Academy, Ankara, Turkey.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|September 12, 2000
PubMed

Insights

This case study identifies ketotifen as a cause of drug fever, confirmed by rechallenge. Recognizing this link is crucial for avoiding unnecessary medical tests and treatments in allergic patients.

Area of Science:

  • Clinical pharmacology
  • Pharmacovigilance
  • Internal medicine

Background:

  • Drug fever is a diagnosis of exclusion.
  • Fever can result from various medications.
  • Prompt recognition is vital to prevent complications.

Observation:

  • A patient developed fever attributed to ketotifen.
  • The drug fever was confirmed through double rechallenge.
  • Ketotifen is an antihistamine used for allergic conditions.

Findings:

  • This case is the first to report ketotifen as a cause of drug fever.
  • The reaction was reproducible upon re-administration of ketotifen.
  • The patient's fever resolved after discontinuing ketotifen.

Implications:

  • Clinicians should consider ketotifen as a potential cause of fever in allergic patients.
  • Failure to identify drug fever can lead to extensive diagnostic workups and prolonged hospital stays.
  • Awareness of ketotifen-induced drug fever can improve patient management and reduce healthcare costs.

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