Signal transduction in primary cultured human erythroid cells

Development of erythrocytes is a complex process governed by multiple cytokines. Colony assays have revealed the physiologic importance of these cytokines, although biochemical studies of highly purified human colony-forming unit-erythroid (CFU-E) generated in vitro from CD34+ cells have only recently begun. Studies from our groups and others suggested that signal transduction in primary erythroid cells differs considerably from that in cell lines or primary cells from other species. In this review, we summarize results of these studies with emphasis on possible implications for hematotherapy.