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Related Experiment Video

Updated: Jul 8, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Aging, habitual exercise, and dynamic arterial compliance.

H Tanaka¹, F A Dinenno, K D Monahan

¹Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309-0354, USA. tanakah@colorado.edu

|September 12, 2000

Summary

Regular aerobic exercise helps maintain large artery flexibility with age. Endurance training improves central arterial compliance, reducing cardiovascular disease risk in middle-aged and older men.

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Area of Science:

Cardiovascular Physiology
Exercise Science
Gerontology

Background:

Reduced central arterial compliance is a risk factor for age-related cardiovascular disease.
Large artery stiffening is a hallmark of aging.
Maintaining arterial health is crucial for preventing cardiovascular events.

Purpose of the Study:

To investigate the impact of habitual exercise on age-related decline in central arterial compliance.
To compare arterial compliance across different activity levels in men of various ages.
To assess the effects of a structured aerobic exercise intervention on arterial compliance.

Main Methods:

Cross-sectional study of 151 healthy men (18-77 years) categorized by activity level (sedentary, recreational, endurance-trained).
Interventional study of 20 middle-aged/older sedentary men undergoing a 3-month aerobic exercise program.
Central arterial compliance measured using B-mode ultrasound and applanation tonometry.

Main Results:

Central arterial compliance decreased with age in all groups.
Endurance-trained men exhibited 20-35% higher arterial compliance than sedentary/recreationally active men.
Aerobic exercise intervention significantly increased arterial compliance in previously sedentary men.

Conclusions:

Regular aerobic-endurance exercise attenuates age-related reductions in central arterial compliance.
Exercise can restore arterial compliance in sedentary middle-aged and older men.
Improved arterial compliance may be a key mechanism reducing cardiovascular disease risk with habitual exercise.