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Pediatric renal transplantation.

Y B Talwalkar, M H Harner, J E Musgrave

    The Western Journal of Medicine
    |July 1, 1975
    PubMed
    Summary
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    Pediatric kidney transplantation offers a successful treatment for end-stage renal failure. This study shows positive outcomes and growth in children receiving kidney transplants from live and cadaver donors.

    Area of Science:

    • Nephrology
    • Pediatric Surgery
    • Immunology

    Background:

    • Pediatric end-stage renal failure necessitates effective treatment options.
    • Kidney transplantation is a viable solution for children with end-stage renal disease.

    Purpose of the Study:

    • To evaluate the outcomes of kidney transplantation in pediatric patients.
    • To assess graft survival rates and long-term complications in children.

    Main Methods:

    • Retrospective analysis of 31 children undergoing 38 kidney transplants.
    • Immunosuppressive therapy included prednisone, azathioprine, and antilymphocyte globulin.
    • Graft survival and patient outcomes were monitored post-transplantation.

    Main Results:

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    • 23 out of 31 patients have functioning allografts post-transplantation.
    • Actuarial one-year survival for live donor allografts was 76%, and for cadaver donors was 50%.
    • Complications included urologic issues and infections; hypertension was linked to chronic rejection or disease recurrence.

    Conclusions:

    • Pediatric renal transplantation is a successful treatment for end-stage renal failure.
    • Transplantation can lead to improved linear growth in pediatric recipients.
    • Long-term graft survival is achievable with appropriate immunosuppression and management.