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New substituted 2-(pyrazol-1-yl) o-, m-, p-methylacetanilides with potential local anaesthetic and antiarrhythmic
M Iovu1, C Zalaru, F Dumitrascu
1University of Medicine and Pharmaceutics Carol Davila, Department of Organic Chemistry, Bucharest, Romania. iovu@gg.unibuc.ro
Farmaco (Societa Chimica Italiana : 1989)
|September 13, 2000
Abstract:
Fifteen substituted 2-(pyrazol-1-yl)acetanilides were synthesized by N-alkylation of pyrazole and some of its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anaesthetic and antiarrhythmic actions. The new compounds have been characterized by elemental chemical analysis, UV-Vis, IR, 1H, 13C NMR spectra and pharmacology research.