Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A rapid procedure to prepare cefotaxime.

J C Rodríguez1, R Hernández, M González

  • 1Departamento de Síntesis Química, Centro de Química Farmacéutica, Ciudad de La Habana, Cuba.

Farmaco (Societa Chimica Italiana : 1989)
|September 13, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MEYER project: Towards a national protocol for in vivo measurement of <sup>131</sup>I in the thyroid of exposed populations in emergencies.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

"Susceptibility of hiPSC-derived NSCs and neurons to paraquat treatment: insights into differential neurotoxicity mechanisms related to mitochondria."

Free radical biology & medicine·2025
Same author

The European intercomparison of in-vivo monitoring laboratories: the EIVIC-2020 project.

Radiation and environmental biophysics·2024
Same author

[In vitro activity of delafloxacin against clinical isolates of carbapenem-resistant Pseudomonas aeruginosa in a stage prior to the clinical use of this drug].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2023
Same author

[Concordance between GeneXpert and Life Real Detection Kit in the diagnosis of acute respiratory infections].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2023
Same author

Multidisciplinary treatment may avoid pelvic exenteration in rectovesical fistula due to locally advanced rectal cancer.

Revista de gastroenterologia de Mexico (English)·2022

A new, rapid method synthesizes cefotaxime efficiently using a readily available reagent. This process offers mild conditions and high yields, improving cefotaxime production.

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Pharmaceutical Synthesis

Background:

  • Cephalosporanic acid derivatives are crucial in antibiotic development.
  • Efficient synthesis of third-generation cephalosporins like cefotaxime is vital for combating bacterial infections.
  • Existing methods for cefotaxime synthesis can be time-consuming and require harsh conditions.

Purpose of the Study:

  • To develop a rapid and efficient synthetic procedure for cefotaxime.
  • To utilize a commercially available reagent for improved accessibility.
  • To establish mild reaction conditions for cefotaxime synthesis.

Main Methods:

  • Acylation of 7-amino cephalosporanic acid with the 2-mercaptobenzothiazolyl thioester of (Z)-2-[2-aminothiazol-4-yl]-2-methoxyimino acetic acid (MAEM).

Related Experiment Videos

  • Reaction conducted at room temperature for 1 hour.
  • Isolation and purification of cefotaxime and 2-mercaptobenzothiazole.

    • Main Results:

    • Achieved a 95% yield of cefotaxime.
    • Recovered 2-mercaptobenzothiazole as a high-purity side-product.
    • Demonstrated a significantly shorter reaction time compared to previous methods.

    Conclusions:

    • The reported method provides a rapid, high-yielding, and mild route for cefotaxime synthesis.
    • The use of a ready-to-use commercial reagent simplifies the process.
    • This procedure offers a practical advancement in the synthesis of cefotaxime.