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Blood loss after coronary artery bypass surgery: relations to patient variables and antithrombotic treatment

S Bjessmo1, T Ivert

  • 1Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden. staffan.bjessmo@swipnet.se

Scandinavian Cardiovascular Journal : SCJ
|September 13, 2000
PubMed

Insights

Acetylsalicylic acid (ASA) can be safely continued before coronary artery bypass surgery. This study found no increased bleeding risk in patients taking ASA, suggesting its continued use is feasible.

Area of Science:

  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Coronary artery bypass surgery (CABS) involves significant blood loss.
  • The use of antiplatelet agents like acetylsalicylic acid (ASA) in patients undergoing CABS requires careful consideration due to potential bleeding risks.

Purpose of the Study:

  • To evaluate the safety of continuing acetylsalicylic acid (ASA) 75 mg/day until the day of isolated coronary artery bypass surgery.
  • To assess the impact of ASA and other factors on blood loss during and after CABS.

Main Methods:

  • Prospective study of 200 patients undergoing coronary artery bypass surgery.
  • Analysis of blood loss, patient demographics, and pre-operative/intra-operative factors.
  • Comparison of bleeding in patients receiving dalteparin/heparin for unstable angina and those taking ASA.

Main Results:

  • Median blood loss was 500 ml during and 600 ml after surgery.
  • Female gender and higher body mass index correlated with less postoperative bleeding.
  • No significant increase in re-exploration for bleeding was observed in patients taking ASA.

Conclusions:

  • Acetylsalicylic acid (ASA) 75 mg/day can be safely continued until the day of isolated coronary artery bypass surgery.
  • Factors like female gender and BMI may influence postoperative bleeding, but ASA treatment did not significantly increase bleeding risk in this cohort.

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