Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural features of human lymphomas.

F Mollo, G Monga, R Coda

    Acta Neuropathologica. Supplementum
    |January 1, 1975
    PubMed
    Summary

    Electron microscopy reclassified many "reticulum cell sarcomas" as "blast cell sarcomas," likely lymphoid. Ultrastructural details aid lymphoma diagnosis, but clear links to surface immunoglobulin data remain elusive.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ostial stenosis of the left main coronary artery in a young woman 10 years after radiation therapy.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma.

    British journal of cancer·2013
    Same author

    MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney tubules, renal vesicles, comma- and s-shaped bodies in human kidney.

    European journal of histochemistry : EJH·2013
    Same author

    The role of immunohistochemistry in the study of the newborn kidney.

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2012
    Same author

    CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis.

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2012
    Same author

    The obesity gene and colorectal cancer risk: a population study in Northern Italy.

    European journal of internal medicine·2011

    Area of Science:

    • Hematopathology
    • Oncology
    • Cell Biology

    Background:

    • Accurate diagnosis of hematological malignancies is crucial for effective treatment.
    • Distinguishing between different types of lymphomas and related conditions can be challenging with light microscopy alone.

    Purpose of the Study:

    • To critically review the diagnostic value of ultrastructural details in various lymphoid and plasma cell neoplasms.
    • To evaluate the utility of electron microscopy in reclassifying cases initially diagnosed by light microscopy, specifically "reticulum cell sarcoma".

    Main Methods:

    • Electron microscopy was used to examine ultrastructural details of 73 lymphomas, 7 thymomas, 6 Waldenström's disease cases, and 5 myelomas.
    • Light microscopy diagnoses were compared with electron microscopy findings.

    Main Results:

    • The diagnosis of "reticulum cell sarcoma" by light microscopy was found to be inadvisable.
    • The majority of cases diagnosed as "reticulum cell sarcoma" were reclassified as "blast cell sarcomas" upon electron microscopic examination, suggesting a lymphoid origin.
    • No clear relationships were established between cell ultrastructure and immunofluorescence data regarding surface immunoglobulin in lymphoid cell populations.

    Conclusions:

    • Electron microscopy provides valuable insights for the accurate classification of lymphomas and related neoplasms.
    • The term "reticulum cell sarcoma" should be reconsidered due to its ambiguity and the frequent misclassification of lymphoid blast cell sarcomas.
    • Further research is needed to correlate ultrastructural findings with immunological markers for a comprehensive understanding of lymphoid malignancies.

    Related Experiment Videos