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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Developmental changes in the relationship between IGF-I and body composition during puberty.

P R Beckett1, W W Wong, K C Copeland

  • 1Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston 77030, USA. pbeckett@bcm.tmc.edu

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|September 13, 2000
PubMed
Summary

During puberty, insulin-like growth factor-I (IGF-I) initially reflects body size in girls. Later, IGF-I levels become associated with physical fitness (VO2max) and body fat percentage.

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Area of Science:

  • Pediatric Endocrinology
  • Human Growth and Development
  • Sports Medicine

Background:

  • Insulin-like growth factor-I (IGF-I) plays a crucial role in growth and metabolism.
  • The relationship between IGF-I, body composition, and physical fitness during puberty is not fully understood.
  • Pubertal development involves significant hormonal and physiological changes impacting growth factors.

Purpose of the Study:

  • To investigate how anthropometric measures and physical fitness influence circulating IGF-I levels during female puberty.
  • To explore the changes in IGF-I, free IGF-I, IGFBP-1, and IGFBP-3 in relation to pubertal development.

Main Methods:

  • Measured IGF-I, free IGF-I, IGFBP-1, and IGFBP-3 in 156 healthy girls aged 9-16 years.
  • Assessed aerobic capacity (VO2max), fat-free mass (FFM), percent fat mass, and pubertal development (Tanner stage).
  • Analyzed correlations between these variables and related them to pubertal progression.

Main Results:

  • IGF-I, free IGF-I, and IGFBP-3 increased with pubertal development; IGFBP-1 decreased.
  • In pre-pubertal girls, IGF-I correlated with weight, height, BMI, and FFM.
  • These correlations diminished by late puberty, with inverse relationships between IGF-I and fat mass, and direct relationships with VO2max emerging.

Conclusions:

  • In early puberty, IGF-I reflects overall somatic size in girls.
  • As puberty progresses, the association shifts from body size to physical fitness and body fatness.
  • These findings highlight dynamic changes in IGF-I regulation during adolescent development.