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Multiple papilloma larynx.

S P Yadav1, A Gera, J Singh

  • 1Department of Otolaryngology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak.

Indian Journal of Pediatrics
|September 14, 2000
PubMed
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Multiple laryngeal papillomas, caused by human papilloma virus, were treated surgically. Postoperative Acyclovir showed promise in preventing recurrence, with three of four patients remaining recurrence-free.

Area of Science:

  • Otolaryngology
  • Virology
  • Oncology

Background:

  • Multiple papilloma of the larynx is a significant clinical challenge.
  • It is caused by the human papilloma virus (HPV).
  • This condition can lead to severe respiratory compromise.

Purpose of the Study:

  • To review the treatment outcomes of multiple laryngeal papilloma cases.
  • To evaluate the efficacy of surgical excision and adjuvant Acyclovir therapy.
  • To identify factors influencing recurrence and complications.

Main Methods:

  • Retrospective analysis of sixteen cases of multiple laryngeal papilloma treated over 10 years.
  • Surgical excision as the primary treatment modality.
  • Adjuvant Acyclovir therapy in a subset of patients post-surgery.

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Main Results:

  • Hoarseness was the most common symptom; six patients experienced respiratory difficulty.
  • Three patients required tracheostomy, with complications including difficult decanulation and laryngotracheal stenosis.
  • Ten out of sixteen patients experienced recurrence after surgical excision.
  • Three of four patients treated with postoperative Acyclovir showed no recurrence.

Conclusions:

  • Surgical excision is the mainstay for multiple laryngeal papilloma but has a high recurrence rate.
  • Postoperative Acyclovir may be an effective adjuvant therapy to reduce recurrence.
  • Laryngotracheal stenosis is a potential severe complication requiring careful management.