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Nonionic Cellulose Ethers as Potential Drug Delivery Systems for Periodontal Anesthesia.
Journal of Colloid and Interface Science
|September 14, 2000
Summary
Nonionic cellulose ethers form gels near body temperature, showing potential for periodontal drug delivery. Interactions with specific surfactants and local anesthetics allow controlled drug release without disrupting gelation.
Area of Science:
- Materials Science
- Polymer Chemistry
- Pharmaceutical Sciences
Background:
- Nonionic cellulose ethers with lower consolute temperature near body temperature are explored for localized drug delivery.
- Ethyl(hydroxyethyl)cellulose (EHEC) and its hydrophobically modified form (HM-EHEC) are key polymers investigated.
- Periodontal pockets present a unique challenge for drug delivery systems.
Purpose of the Study:
- To investigate the potential of cellulose ether-based systems for local anesthetic delivery to the periodontal pocket.
- To determine the interactions between EHEC, HM-EHEC, and ionic surfactants in the presence and absence of local anesthetics.
- To evaluate the effect of local anesthetics on polymer-surfactant interactions and drug release.
Main Methods:
- Cloud-point and rheology measurements were used to study polymer-surfactant interactions.
- In vitro drug release studies were conducted.
- Temperature-dependent viscosity was monitored.
- The influence of lidocaine and prilocaine on EHEC/surfactant systems was assessed.
Main Results:
- Interactions between EHEC/HM-EHEC and both anionic and cationic surfactants were confirmed.
- Ionic surfactants increased cloud-point, induced concentration-dependent thickening, and caused temperature-induced gelation.
- Local anesthetics (lidocaine, prilocaine) had minor direct interaction with polymers but affected polymer-surfactant interactions.
- Drug release rates and system stability were evaluated for EHEC/SDS and EHEC/myristoylcholine bromide systems with added anesthetics.
Conclusions:
- Cellulose ether systems can incorporate local anesthetics for periodontal delivery without significantly compromising gelation.
- The EHEC/myristoylcholine bromide system is particularly promising due to the surfactant's antibacterial and biodegradable properties.
- These findings suggest a viable approach for developing effective periodontal drug delivery formulations.