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The pathology of essential fatty acid deficiency: is it cell adhesion mediated?
W G Jiang1, A R Eynard, R E Mansel
1Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, UK. jiangw@cf.ac.uk
Medical Hypotheses
|September 14, 2000
Abstract:
For almost 70 years, essential fatty acid deficiency has been known to be associated with skin disorders, vessel abnormalities, and increased tumorigenesis. However, the underlying molecular and cellular mechanism is largely unknown. Recently, it has been reported that essential fatty acids regulate cell adhesion by modifying the expression of cell adhesion molecules. These findings may provide molecular explanations for those phenomena seen in EFAD and this paper aims to discuss these relationships and raise points for further discussion.