Related Experiment Videos
Pre-implantation genetic diagnosis.
1Department of Obstetrics & Gynaecology, University College London, 86-96 Chenies Mews, London, WC1E 6HX, UK.
Bailliere'S Best Practice & Research. Clinical Obstetrics & Gynaecology
|September 14, 2000
Summary
Pre-implantation genetic diagnosis (PGD) offers genetic testing for embryos before pregnancy. This review details PGD technology, applications, and its global expansion for inherited diseases.
Area of Science:
- Reproductive Medicine
- Medical Genetics
- Embryology
Background:
- Pre-implantation genetic diagnosis (PGD) has been established for over a decade.
- Over 40 international centers now offer PGD services.
- More than 150 babies have been born following PGD at the cleavage stage (day 3 of development).
Purpose of the Study:
- To review the current status and technological advancements in PGD.
- To outline the spectrum of genetic diseases for which PGD testing is available.
- To provide an overview of PGD's global implementation and outcomes.
Main Methods:
- Review of existing literature and clinical data on PGD.
- Analysis of PGD technologies employed in various centers.
- Categorization of genetic diseases targeted by PGD.
Main Results:
- PGD is a globally utilized technique with significant growth in the last 10 years.
- Established protocols for genetic testing on day 3 embryos (cleavage stage).
- Wide range of genetic disorders can be screened using PGD.
Conclusions:
- PGD is a mature technology with proven success in preventing the transmission of genetic diseases.
- Continued development in PGD technology enhances its diagnostic capabilities.
- PGD plays a crucial role in reproductive choices for at-risk couples.