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First total synthesis of dragmacidin A via indolylglycines
T Kawasaki1, H Enoki, K Matsumura
1Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588 Japan. kawasaki@my-pharm.ac.jp
Organic Letters
|September 15, 2000
Abstract:
The first total synthesis of dragmacidin A has been accomplished using condensation of two indolylglycines followed by cyclization and reduction. The general and practical method for synthesis of indolylglycines via Wittig reaction, azide addition, and reduction from indolin-3-ones is also described.