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Related Experiment Videos

Biochemical screening for Down syndrome.

H Cuckle1

  • 1Reproductive Epidemiology, Centre for Reproduction, Growth and Development, School of Medicine, University of Leeds, 26 Clarendon Road, LS2 9NZ, Leeds, UK. h.s.cuckle@leeds.ac.uk

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|September 15, 2000
PubMed
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Maternal serum screening effectively detects Down syndrome using multiple markers in both first and second trimesters. Adding more markers, like inhibin A or ultrasound, improves detection rates while maintaining low false positives.

Area of Science:

  • Prenatal diagnostics
  • Biochemical markers
  • Maternal serum screening

Background:

  • Maternal serum screening is a standard practice for detecting Down syndrome.
  • Established markers include human chorionic gonadotrophin (hCG), alpha-fetoprotein (AFP), and unconjugated estriol (uE3).

Purpose of the Study:

  • To evaluate the effectiveness of multi-marker screening for Down syndrome in both trimesters.
  • To assess the impact of additional markers on detection rates and false positives.
  • To explore screening for Edwards' syndrome and associations with adverse pregnancy outcomes.

Main Methods:

  • Utilizing statistical models based on meta-analysis of prospective studies.
  • Analyzing combinations of biochemical markers: free beta-hCG, AFP, uE3, and inhibin A.

Related Experiment Videos

  • Incorporating ultrasound nuchal translucency measurements in first-trimester screening.

    • Main Results:

    • Second-trimester screening with three markers achieves a 67% detection rate at 5% false-positive rate.
    • Adding inhibin A increases detection by 7% without raising the false-positive rate.
    • First-trimester screening with four markers and ultrasound reaches an 88% detection rate.

    Conclusions:

    • Multi-marker maternal serum screening is highly effective for Down syndrome and Edwards' syndrome.
    • Additional markers and ultrasound significantly enhance detection rates.
    • High-quality information is crucial for managing patient anxiety during screening.