Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Assessment of diastolic dysfunction. Invasive modalities.

D A Kass1

  • 1Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. dkass@bme.jhu.edu

Cardiology Clinics
|September 15, 2000
PubMed
Summary

Invasive methods using micromanometer and conductance catheters are the gold standard for assessing diastolic function, specifically chamber relaxation and compliance. Careful analysis is crucial, though noninvasive techniques are advancing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pressure Overload and Cardiac Remodelling-A Smoking Gun Points to Uncoupled Nitric Oxide Synthase: Oxidant Stress from Nitric Oxide Synthase-3 Uncoupling Stimulates Cardiac Pathologic Remodeling from Chronic Pressure Load. J Clin Invest 115: 1221-1231, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice.

American journal of physiology. Heart and circulatory physiology·2006
Same author

Noninvasive single-beat determination of left ventricular end-systolic elastance in humans.

Journal of the American College of Cardiology·2001
Same author

Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy.

Circulation·2001
Same author

Enhancement of contrast echocardiography by image variability analysis.

IEEE transactions on medical imaging·2001
Same author

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.

Proceedings of the National Academy of Sciences of the United States of America·2001

Area of Science:

  • Cardiology
  • Physiology

Background:

  • Diastolic function is crucial for cardiac health.
  • Accurate assessment of diastolic function is challenging.

Purpose of the Study:

  • To review invasive methodologies for assessing diastolic function.
  • To highlight the gold standard methods for chamber relaxation and compliance.

Main Methods:

  • Utilizing micromanometer catheters for chamber relaxation.
  • Combining micromanometer and conductance catheters for chamber compliance.
  • Analyzing data from multiple cardiac cycles.

Main Results:

  • Invasive methods provide accurate assessment of diastolic properties.
  • Analysis involves physiological and mathematical assumptions.

Related Experiment Videos

  • Potential for misleading interpretations if assumptions are not met.

    • Conclusions:

    • Careful data collection and analysis are essential for accurate interpretation.
    • Noninvasive methods are evolving but invasive techniques remain the gold standard.
    • Invasive methods have been pivotal in understanding and treating diastolic dysfunction.