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Role of angiogenesis in benign, premalignant and malignant vulvar lesions
A B MacLean1, W M Reid, K J Rolfe
1Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, London, U.K.
Objective:
To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions.
Study Design:
Immunohistochemical demonstration of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in normal vulvar skin, lichen sclerosus, vulvar intraepithelial neoplasia (VIN) and vulvar cancer.
Results:
VEGF was found in the majority of vulvar cancers but only a minority of VIN lesions. PD-ECGF was found in the majority of lesions.
Conclusion:
Demonstration of angiogenesis may suggest which preinvasive lesions will progress to invasive cancer.