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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
[Fatal intracerebral gas gangrene in a 10-month-old child]
S Bele1, A Fiedler, C Woertgen
1Klinik und Poliklinik für Neurochirurgie, Universität Regensburg.
Insights
Intracerebral gas-forming bacterial infections are rare, often resulting from penetrating trauma. Despite treatment, a severe case of gas gangrene encephalitis in a child led to a fatal outcome due to rapid brain swelling.
Area of Science:
- Neurology
- Infectious Diseases
- Bacteriology
Background:
- Intracerebral infections caused by gas-forming bacteria are uncommon, typically associated with penetrating head trauma.
- While often severe, outcomes for such infections can be favorable with prompt surgical and antibiotic interventions.
Observation:
- A 10-month-old boy sustained a pecking injury above the left ear, causing temporal bone and dura perforation.
- Within 48 hours, the child developed rapidly progressing gas gangrene encephalitis.
Findings:
- The infection was identified as Clostridium perfringens gas gangrene encephalitis.
- Despite aggressive surgical and antibiotic treatment, the patient succumbed to massive brain swelling and cardiorespiratory failure.
Implications:
- This case highlights the potential for rapid, fatal progression of Clostridium perfringens infections in the brain, even with treatment.
- It underscores the critical need for swift diagnosis and intervention in rare cases of traumatic brain injury complicated by gas-forming bacteria.
Abstract:
Today, intracerebral infections by gas forming bacteria are very rare. They are mostly seen after penetrating injuries and more rarely after trivial trauma. Although prognosis of this kind of infection is severe, the general outcome of these patients after surgical and antibiotic treatment is good. We report a ten months old boy suffering a pecking injury just above the left ear with perforation of the temporal bone and dura. In between 48 hrs he developed a rapidly progressive gas gangrene encephalitis due to infection with C. perfringens and died despite of surgical and antibiotic treatment due to massive brain swelling and cardio-pulmonary failure.
Related Concept Videos
Acute Respiratory Failure-III
Bacterial Meningitis I: Introduction
Brain Abscess l: Introduction

