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Hepatic schistosomiasis.

I Bica1, D H Hamer, M J Stadecker

  • 1Department of Medicine, New England Medical Center, Boston, Massachusetts, USA.

Infectious Disease Clinics of North America
|September 15, 2000
PubMed
Summary
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Schistosomiasis, caused by Schistosoma mansoni, leads to severe organ damage and mortality worldwide. This review covers its epidemiology, pathogenesis, clinical impact, and control strategies.

Area of Science:

  • Tropical medicine
  • Parasitology
  • Immunology

Background:

  • Schistosomiasis is a significant global health issue causing widespread morbidity and mortality.
  • Infection by Schistosoma mansoni leads to egg deposition in organs like the liver and intestines, triggering a granulomatous host response.

Purpose of the Study:

  • To provide a comprehensive overview of schistosomiasis.
  • To discuss epidemiology, immunopathogenesis, clinical manifestations, and diagnostic and therapeutic strategies.

Main Methods:

  • Review of existing literature on schistosomiasis.
  • Synthesis of information on disease mechanisms, clinical presentations, and management.

Main Results:

  • Schistosomiasis manifests in intestinal and hepatosplenic forms, with the latter causing hepatic fibrosis and portal hypertension.

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  • The article details the disease's epidemiology, immunopathogenesis, and clinical spectrum.

    • Conclusions:

    • Effective control strategies are crucial for managing schistosomiasis globally.
    • Understanding the interplay between hepatic schistosomiasis and viral infections is important for comprehensive patient care.