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DNA triple helix stabilization by aminoglycoside antibiotics
1Department of Chemistry, Clemson University, SC 29634, USA. dparya@clemson.edu
Bioorganic & Medicinal Chemistry Letters
|September 15, 2000
Abstract:
The stabilization of the poly(dA) x 2poly(dT) triple helix by neomycin is reported. Preliminary results indicate that neomycin stabilizes DNA triple helices and the double helical structures composed of poly(dA) x poly(dT) are virtually unaffected. This is the first report of the interaction of aminoglycoside antibiotics with DNA triple helices.