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Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor
K Sugano1, S Yoshida, M Takaku
1Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd, Shizuoka, Japan. suganokyh@chugai-pharm.co.jp
Bioorganic & Medicinal Chemistry Letters
|September 15, 2000
Abstract:
The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity.