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Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide
I S Blagbrough1, A J Geall, S A David
1Department of Pharmacy and Pharmacology, University of Bath, UK. prsisb@bath.ac.uk
Bioorganic & Medicinal Chemistry Letters
|September 15, 2000
Abstract:
Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.