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Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide
R J Mathvink1, J S Tolman, D Chitty
1Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. robert_mathvink@merck.com
Bioorganic & Medicinal Chemistry Letters
|September 15, 2000
Abstract:
A series of thiazole benzenesulfonamide-substituted 3-pyridylethanolamines was prepared and evaluated for their human beta3 adrenergic receptor agonist activity. Incorporation of aryl and heteroaryl substitution in the 4-position of the thiazole ring resulted in a number of highly potent and selective beta3 agonists. Results of preliminary in vivo evaluation of several of these compounds is described.