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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Nosocomial respiratory syncytial virus infections: the "Cold War" has not ended
1Departments of Pediatrics and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Caroline_Hall@urmc.rochester.edu
Insights
Respiratory syncytial virus (RSV) poses a significant nosocomial risk, especially in pediatric and transplant settings. Effective infection control, including hand hygiene and staff education, is crucial to prevent its spread and manage patient outcomes.
Area of Science:
- Infectious Diseases
- Hospital Epidemiology
- Pediatrics
Background:
- Respiratory syncytial virus (RSV) is a common cause of nosocomial infections, particularly on pediatric wards.
- Infections are most severe in infants and immunocompromised individuals, including transplant recipients.
- Nosocomial RSV can present atypically, leading to diagnostic delays and increased healthcare costs.
Purpose of the Study:
- To highlight the risks and challenges associated with nosocomial RSV infections.
- To emphasize the importance of infection control measures in preventing RSV transmission.
- To inform healthcare professionals about RSV manifestations and transmission routes.
Main Methods:
- Review of existing literature on RSV nosocomial infections.
- Analysis of transmission routes, including fomites and direct contact.
- Discussion of clinical manifestations in various patient populations.
Main Results:
- RSV poses a significant threat in healthcare settings, with high morbidity and mortality in vulnerable populations.
- Medical staff play a role in RSV transmission, underscoring the need for education.
- Atypical presentations in neonates and immunosuppressed patients complicate diagnosis.
Conclusions:
- Comprehensive infection control programs are essential for managing nosocomial RSV.
- Hand washing is a primary infection control measure.
- Institutional policies for barrier controls should be tailored to patient populations and cost-effectiveness.
Abstract:
Respiratory syncytial virus (RSV) is a major nosocomial hazard on pediatric wards during its annual outbreaks. It produces significant morbidity in young children and is most severe in those with underlying conditions, especially cardiopulmonary and immunosuppressive diseases. In older patients, RSV may exacerbate an underlying condition or pulmonary and cardiac manifestations. On transplant units, of RSV may be occult and is associated with high mortality rates. The manifestations of nosocomial RSV infections may be atypical, especially in neonates and immunosuppressed patients, resulting in delayed or missed diagnosis and adding appreciably to the costs of hospitalization. RSV is primarily spread by close contact with infectious secretions, either by large-particle aerosols or by fomites and subsequent self-inoculation, and medical staff are often instrumental in its transmission. Thus, integral to any infection control program is the education of personnel about the modes of transmission, the manifestations, and the importance of RSV nosocomial infections. Hand washing is probably the most important infection control procedure. The choice of barrier controls should be decided by individual institutions depending on the patients, the type of ward, and the benefit relative to cost.
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