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What does a common channel for electrolytes and non-electrolytes in the sperm mean?
1Department of Biotechnology, University of Pune, Pune, 411 007, India. sitaram@unipune.ernet.in
Journal of Theoretical Biology
|September 16, 2000
Abstract:
Cell volume is central to osmoregulation in intact cells. Bovine spermatozoa, as also other mammalian spermatozoa, exhibit a very rapid regulatory volume decrease (RVD) when exposed to hypotonic saline media. This response, fastest known in animal cells, is mediated by a putative potassium channel which the pharmacological properties of a conventional channel and yet admits both electrolytes and non-electrolytes. The evolutionary basis and functional role of this conserved quinine-sensitive channel in mammalian sperm could offer hitherto unexplored facets of the link(s) between ecology and reproduction.