Carbohydrate sulfotransferases in lymphocyte homing
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Updated: Oct 13, 2026

Competitive Homing Assays to Study Gut-tropic T Cell Migration
Published on: March 1, 2011
1Department of Respiratory Diseases, Roche Bioscience, Palo Alto, CA 94304-1397, USA.
Abstract:
Sulfation is a critical modification in many instances of biological recognition. Early work in lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of carbohydrate sulfotransferases capable of generating these modifications has been identified at the molecular level. Reconstitution experiments implicate members of this family as critical participants in lymphocyte homing.
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