Jove
Visualize
Contact Us

Related Experiment Videos

Sperm centriole disfunction and sperm immotility.

Z P Nagy1

  • 1Clínica e Centro de Pesquisa em Reprodução Humana Roger Abdelmassih, Rua Maestro Elias Lobo 805, Jardim Paulista, 01433-000, SP, São Paulo, Brazil. clinica.sp@dglnet.com.br

Molecular and Cellular Endocrinology
|September 16, 2000
PubMed
Summary

Asthenozoospermia, characterized by poor sperm motility, stems from non-viable sperm or ultrastructural defects. Intracytoplasmic sperm injection (ICSI) offers effective treatment for many cases, addressing fertilization and embryo development issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of oocyte donor stimulation on recipient outcomes: data from a US national donor oocyte bank.

Human reproduction (Oxford, England)·2020
Same author

A review of the promises and pitfalls of oocyte and embryo metabolomics.

Placenta·2011
Same author

Vitrification in assisted reproduction: myths, mistakes, disbeliefs and confusion.

Reproductive biomedicine online·2009
Same author

Co-transfer of embryos derived from cryopreserved and fresh natural cycle oocytes: a pilot study.

Reproductive biomedicine online·2008
Same author

A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2005
Same author

Fertilizable oocytes reconstructed from patient's somatic cell nuclei and donor ooplasts.

Reproductive biomedicine online·2003
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Reproductive biology
  • Human embryology
  • Andrology

Background:

  • Asthenozoospermia, defined by reduced sperm motility, is primarily caused by necrozoospermia or sperm ultrastructural abnormalities.
  • Sperm centrosome alterations can impact sperm function, leading to impaired motility and potential fertilization defects.
  • Paternal inheritance of the centrosome in humans links its morphology and function to oocyte fertilization and early embryo development.

Purpose of the Study:

  • To elucidate the causes and consequences of asthenozoospermia.
  • To explore the role of sperm centrosome abnormalities in male infertility.
  • To review current treatment strategies for asthenozoospermia.

Main Methods:

  • Review of literature on asthenozoospermia etiology and ultrastructural sperm defects.

Related Experiment Videos

  • Analysis of the impact of centrosome abnormalities on sperm function and fertilization.
  • Evaluation of intracytoplasmic sperm injection (ICSI) and other assisted reproductive technologies.

    • Main Results:

    • Necrozoospermia and ultrastructural sperm abnormalities are key causes of asthenozoospermia.
    • Sperm centrosome defects can lead to fertilization and embryo cleavage issues.
    • Intracytoplasmic sperm injection (ICSI) with hypo-osmotic swelling test (HOST) or testicular sperm is an effective treatment.

    Conclusions:

    • Asthenozoospermia has diverse causes, including sperm structural defects impacting motility and fertilization.
    • ICSI represents a successful therapeutic approach for managing asthenozoospermia.
    • Centrosome replacement with donor sperm is not currently a viable treatment option.