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Related Experiment Videos

Visual pathway tumors and hydrocephalus.

A Shuper1, L Kornreich, S Michowitz

  • 1Department of Pediatric Oncology/Hematology, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel. dnaomi@clalit.org.il

Pediatric Hematology and Oncology
|September 16, 2000
PubMed
Summary
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Hydrocephalus impacts children with visual pathway tumors (VPT), especially those with neurofibromatosis (NF). Early shunting is crucial for VPT patients with NF to prevent vision loss from increased intracranial pressure.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Ophthalmology

Background:

  • Visual pathway tumors (VPT) are a significant concern in pediatric neuro-oncology.
  • Hydrocephalus can complicate the clinical course of VPT, particularly in patients with neurofibromatosis (NF).

Purpose of the Study:

  • To evaluate the impact of hydrocephalus on the clinical presentation of children diagnosed with VPT.
  • To compare the incidence and characteristics of hydrocephalus in VPT patients with and without NF.

Main Methods:

  • Retrospective chart review of children with VPT treated since 1985.
  • Selection and summarization of cases involving hydrocephalus.

Main Results:

  • Thirty-five children with VPT were identified; 20 had NF.

Related Experiment Videos

  • Hydrocephalus occurred in 20% of NF patients with VPT and 33.3% of non-NF patients with VPT.
  • Six children presented with acute increased intracranial pressure requiring immediate shunting; 3 NF patients developed hydrocephalus due to aqueductal stenosis, causing severe vision loss in two.

    • Conclusions:

    • Hydrocephalus is more frequent in VPT patients with NF than in the general NF population but less frequent than in VPT patients without NF.
    • Indolent hydrocephalus development, particularly from aqueductal stenosis, should be monitored in children with NF and VPT.
    • Ventricular dilatation in VPT patients with NF warrants consideration for early shunting due to optic nerve vulnerability.