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[Hepatitis C virus and chronic hepatopathies in Dakar: case-control study]
P S Mbaye1, Y Renaudineau, A Diallo
1Service de Médecine Interne et d'Hépato-Gastroentérologie de l'Hôpital Principal de Dakar, Sénégal.
Medecine Tropicale : Revue Du Corps De Sante Colonial
|September 16, 2000
Summary
Hepatitis C virus (HCV) plays a minor role in chronic liver disease in Senegal. Hepatitis B virus is the predominant cause, often complicated by delta hepatitis virus.
Area of Science:
- Hepatology
- Virology
- Epidemiology
Context:
- The role of Hepatitis C Virus (HCV) in chronic liver disease in Black Africa, particularly Senegal, remains unclear.
- Senegal exhibits a moderate prevalence of HCV, necessitating further investigation into its etiological contribution to hepatic diseases.
Purpose:
- To investigate the role of HCV in chronic hepatic diseases in Senegal.
- To compare HCV's impact on liver disease in Senegal with other Black African countries.
Summary:
- A case-control study in Dakar (1995) involving 73 patients with chronic hepatitis, cirrhosis, or hepatocellular carcinoma and 73 controls found only 3% of patients tested positive for HCV antibodies.
- Hepatitis B virus (HBV) was highly prevalent in both patients (74%) and controls (21%), with a significant proportion of patients (24%) also infected with the delta hepatitis virus.
- The study concludes that HCV plays a minor role in hepatic disease among hospitalized patients in Senegal, highlighting HBV as the primary etiological agent.
Impact:
- This research indicates a lower impact of HCV on liver disease in Senegal compared to Central Africa.
- The findings underscore the predominant role of HBV and the complicating effect of delta hepatitis virus in the region's liver disease burden.