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Related Experiment Videos

Does desensitization to hexarelin occur?

A Rahim1, S M Shalet

  • 1Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|September 16, 2000
PubMed
Summary
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Long-term administration of hexarelin, a growth hormone (GH)-releasing peptide, causes a partial and reversible decrease in GH release. This study in elderly individuals shows the GH response recovers after therapy cessation.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Hexarelin is a potent growth hormone (GH)-releasing peptide.
  • Potential therapeutic applications of hexarelin may be limited by GH response attenuation during long-term use.

Purpose of the Study:

  • To investigate the effect of 16-week, twice-daily subcutaneous hexarelin administration on GH release in healthy elderly individuals.

Main Methods:

  • 12 healthy elderly individuals received twice-daily subcutaneous hexarelin injections for 16 weeks.
  • Growth hormone release was assessed by measuring the area under the GH curve (AUCGH) at baseline and at weeks 1, 4, and 16.
  • GH response was re-evaluated 4 weeks after the 16-week treatment period.

Main Results:

  • A significant decrease in mean AUCGH was observed over the 16-week study period (P = 0.0003).

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  • Significant reductions in AUCGH were noted at week 4 (P < 0.05) and week 16 (P < 0.01) compared to baseline.
  • Four weeks after treatment cessation, GH response (AUCGH) significantly increased (P < 0.05) and was comparable to baseline levels.

    • Conclusions:

    • Long-term administration of hexarelin leads to a partial attenuation of the GH response.
    • The observed attenuation of GH release following long-term hexarelin therapy is reversible.
    • These findings suggest that hexarelin's therapeutic potential is not severely limited by tachyphylaxis.