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Chlorpromazine-induced electrocardiogram abnormalities.

G Chouinard, L Annable, Melançon

    International Journal of Clinical Pharmacology and Biopharmacy
    |June 1, 1975
    PubMed
    Summary
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    This study found that most schizophrenic patients on chlorpromazine had normal electrocardiograms (ECGs). Factors like sex, age, or illness duration did not significantly impact ECG abnormalities in patients receiving this antipsychotic medication.

    Area of Science:

    • Psychiatry
    • Cardiology

    Background:

    • Schizophrenia treatment often involves antipsychotic medications like chlorpromazine.
    • Electrocardiographic (ECG) changes are a known potential side effect of some antipsychotics.

    Purpose of the Study:

    • To evaluate electrocardiographic abnormalities in patients treated solely with chlorpromazine.
    • To determine if sex, age, or duration of illness influence these ECG abnormalities.

    Main Methods:

    • 96 schizophrenic patients were switched to a fixed daily dose of 125 mg chlorpromazine for two weeks.
    • ECGs were recorded after an overnight fast.
    • Chi-square tests were used to analyze the data.

    Main Results:

    • 65.9% of patients had normal ECGs; 34.1% showed abnormalities.

    Related Experiment Videos

  • Repolarization abnormalities were observed in 11% (Grade I), 14.3% (Grade II), and 8.8% (Grade III).
  • No significant differences in ECG normality or abnormality grade were found based on sex, age, or length of illness.

    • Conclusions:

    • Chlorpromazine treatment at 125 mg/day resulted in normal ECGs for the majority of schizophrenic patients.
    • Sex, age, and illness duration do not appear to be significant factors influencing chlorpromazine-related ECG changes in this cohort.