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Updated: Aug 17, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
The molecular basis of growth hormone action
1Department of Internal Medicine, University of Iowa College of Medicine, VA Medical Center, Iowa City 52246, USA. mthomas@icva.gov
Abstract:
Recent studies have begun to elucidate the molecular actions of growth hormone, a major regulator of somatic growth and metabolic functions. The cell surface growth hormone receptor, a member of the cytokine receptor superfamily, binds as a dimer to a single growth hormone molecule. Receptor dimerization precedes signal transduction, which is predominantly mediated by the non-receptor tyrosine kinase, Jak2. Activation of Jak2 leads to mitogenic proliferation, phosphorylation of intracellular proteins, MAP kinase activation, activation of Stats 1, 3, and 5, and induction of target gene expression. Specific cytoplasmic domains of the growth hormone receptor mediate Jak2 activation, metabolic actions of growth hormone, Stat activation, and calcium influx.
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